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Scientific Papers and Articles on Hyperthermia Clinical Trials,
Head and Neck Cancer

• Recent advances in preoperative hyperthermochemoradiotherapy for patients with esophageal cancer
• Effectiveness of RF capacitive hyperthermia combines with radiotherapy for Stages III and IV oro-hypopharyngeal cancers: a non-randomized comparison between thermoradiotherapy and radiotherapy
• Report of long-term follow-up in a randomized trial comparing radiation therapy and radiation therapy plus hyperthermia to metastatic lymphnodes in stage IV head and neck patients

Publications by James Bicher containing clinical results

1. Bicher HI, Bruley DF. Hyperthermia. Plenum Press, New York, 1982.
2. Bicher HI, Hetzel FW, Sandhu TS. Thermoradiotherapy in Hyperthermia. Ed. K Storm. K Hall Publisher, New York, 1982.
3. Johnson RJR, Bicher HI, Hetzel FW, Sandhu TS, Kowal HS. The use of either regional or wholebody hyperthermia as an adjunctive treatment with radiotherapy. Proc of Conf on Clinical Prospects of Hypoxic Cell Sensitizers and Hyperthermia, Madison, September, 1977, 324329.
   
4. Johnson R, Sandhu TS, Hetzel FW, Song SY, Bicher HI, Kowal H. A pilot study to investigate skin and tumor thermal enhancement ratio of hyperthermia (41.5 42C) with radiation. Int J. Radiat Oncol Biol Phys 1979, 5:947953.
   
5. Bicher HI, Sandhu TS, Hetzel FW. Hyperthermia as a radiation adjuvant: An effective fractionation regime. Int. J. Radiat Oncol Biol Phys 1979; 171.
   
6. Bicher HI, Hetzel FW, Sandhu TS. Physiological and clinical effects of microwave hyperthermia. Advances in Engineering 1979; 139.
   
7. Bicher HI, Sandhu TS, Hetzel FW. Hyperthermia and radiation in combination. Int J. Radiat Oncol Biol Phys 1980, 6:867870.
   
8. Bicher HI, Sandhu TS, Hetzel FW. Hyperthermia fractionation protocol: Preliminary results of a clinical trial. Presented at the Third International Symposium on Cancer Therapy by Hyperthermia, Drugs and Radiation. Fort Collins, Colorado, June 2226, 1980.
9. Bicher HI, Sandhu TS, Hetzel FW, Matvia F. The clinical use of intracavitary antennae in the treatment of deep seated tumors with microwave induced hyperthermia. Presented at the American Society of Therapeutic Radiologists (ASTR) 22nd Annual Meeting, Dallas, Texas, October 2125, 1980.
   
10. Bicher HI, Sandhu TS, Hetzel FW. Fractionated hyperthermia in combination with radiation: Clinical results. Presented at (ASTR) 22nd Annual Meeting, Dallas, Texas, October 2125, 1980.
    
11. Bicher HI, Sandhu TS, Hetzel FW. Clinical thermoradiotherapy Henry Ford Hospital Med. J. 1981, 29:915.
    
12. Bicher HI. Status of ongoing clinical trials with microwave hyperthermia. Brit J. Cancer 1982, 45:247248.
    
13. Bicher HI. Hyperthermia, clinical results. In progress in RadioOncolgy II. 409413 (ed). K.H. Karcher, Raven Press, New York, 1982.
    
14. Bicher HI, Hetzel FW, Sandhu TS. Results of a phase I/II clinical trial of fractionated hyperthermia in combination with low dose ionizing radiation. Adv Exp Med Biol 1982, 157:8797.
    
15. Bicher HI, Hetzel FW, Sandhu TS. Results of phase I/II clinical trial of fractionated hyperthermia in combination with low dose ionizing radiation. Advances in Experimental Medicine and Biology, 157: 8797, 1983.
    
16. Bicher HI, Fingerhut AG, Frey HS, Lewinsky BS, Metcalf D, Syed N. A method of interstitial thermoradiotherapy. (Meeting Abstract). Fift MidWinter Meeting of the American Endocurietherapy Society, December 810, 1982, Key Biscayne, Florida. American Endocurietherapy Society; 50, 1982.
    
17. Bicher HI, Fingerhut AG, Frey HS, Lewinsky BS, Metcalf D. A system for hyperthermia retreatment of radiation failures in a free standing radiation therapy center. (Meeting abstract). ThirtyFirst Annual Meeting of the Radiation Research Society, February 27 March 3, 1983, San Antonio, Texas, Radiation Research, 145, 1983.
    
18. Bicher HI. The setup of state of the art hyperthermia clinictherapeutic, ethical and practical considerations. Frontiers in Radiation Therapy Oncology, 18:153161;1984.
    
19. Bicher HI, Wolfstein RS. Microwave hyperthermia as an adjuvant to radiation therapy. Summary experience of 208 multifraction treatment cases. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and Philadelphia, 1:363366, 1984.
    
20. Bicher HI, Wolfstein RS, Fingerhut AG, Frey HS, Lewinsky BS. An effective fractionation regime for interstitial thermoradiotherapy. Preliminary clinical results. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and Philadelphia, 1:575578, 1984.
    
21. Bicher HI, Wolfstein RS, Fingerhut AG, Lewinsky BS, Frey HS. Clinical multified controlled comparison of the hyperthermia and low dose radiation to full dose radiation of chest wall recur rence. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and Philadelphia, 1:391394, 1984.
    
22. Bicher HI, Mitagvaria NP. Changes in tumor tissue oxygenation during microwave hyperthermia clinical relevance. Proceedings of the 4th International Symposium on Hyperthermic Oncology, Taylor and Francis LTD, London and Philadelphia, 1:169172, 1984.
    
23. Bicher HI, Moore DW, Wolfstein RS. Aircooled 300MHz applicators used in a parallel opposed phase system (POPAS). Int. J. Radiat Oncol Biol Phys, 11:S1:217, 1985.
    
24. Bicher HI, Wolfstein RS, Moore DW. A method for Interstitial thermoradiotherapy preliminary clinical results. Endocurie, Hyperthermia Oncology, 1:136, 1985. (Abstract).
    
25. Bicher HI, Wolfstein RS. Local hyperthermia for deep tumors, experience with three techniques. J. Microwave Power 1986; 21st International Microwave Power Symposium Summaries:103.
    
26. Bicher HI, Wolfstein RS, Lewinsky BS, Frey HS, Fingerhut AG. Microwave hyperthermia an adjunct to radiation therapy: Summary experience of 256 multifraction treatment cses. Int J Rad Onc Biol Phys 1986, 12:16671671.
    
27. Bicher HI, Wolfstein RS, Chatham PL. Hyperthermic adjunct treatment for specific sites: nasopharynx, pancreas, liver, chest and pelvis. Preliminary experience. Int. J. Hyperthermia 3:551, 1987 (Abstract).
    
28. Bicher HI, Afuwape SA. A three applicator microwave phased array system (TRIPAS). Featuring mathematical prediction and relocation of the hyperthermia clinical target "Hot spot". J. Microwave Power, 22:173-178, 1987.
    
29. Bicher HI, Wolfstein RS. Treatment of intratoracic lesions. Preliminary results (Abstract). 37th Annual Meeting of the Radiation Research Society. 3:1823, 1989.
    
30. Bicher HI, Wolfstein RS. Hyperthermia treatment for abdominal tumors (Abstract). 37th Annual Meeting of the Radiation Research Society, 3:1823, 1989.
    
31. Bicher HI, Wolfstein RS. Local superficial and deep hyperthermia. Factors affecting tumor response and patient survival (Abstract). 37th Annual Meeting of the Radiation Research Society, 3:1823, 1989.
    
32. Bicher HI, Wolfstein RS. Hyperthermia palliation of bone pain (Abstract). The 13th International Symposium on Clinical Hyperthermia, 5:2125, 1990.
    
33. Bicher HI, Wolfstein RS. Clinical use of regional hyperthermia. Adv in Exp Med and Biol. Plenum Press, New York, 267: 120, 1990.
    
34. Bicher HI, Wolfstein RS. Local hyperthermia for superficial and moderately deep tumors. Factors affecting response. Adv in Exp Med and Biol. Plenum Press, New York, 267: 353367, 1990.
    
35. Bicher HI, Wolfstein RS. Local hyperthermia for deep tumors. Adv in Exp Med and Biol. Plenum Press, New York, 267:411422, 1990.
    
36. Bicher HI,Lung paper? (Abstract). Proceeding of the 14th International Symposium on Clinical Hyperthermia (ICHS), Dubna, USSR, May 20-24, 1991.
    
37. Bicher HI, Wolfstein RS. Local Hyperthermic Treatment for Cancer in Aids Patients (Abstract). Proceeding of the 9th International Congress of Radiation Research (ICRR). Toronto, Canada, July 7-12, 1991.
    
38. Bicher HI, Wolfstein RS. Direct Relation Between Thermal Dose and Tumor Response in Hyperthermia Therapy (Abstract). Proceeding of the 77th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA).Chicago, Illinois. December 1-6, 1991.
    
39. Bicher HI, Mitagvaria N. Oxygen and pH in Human Tumors During Hyperthermia (Abstract). Proceeding of the XV International Symposium on Clinical Hyperthermia (ICHS). Lyon, France, May 19-22, 1992.
    
40. Bicher HI, Wolfstein RS. Hyperthermia for Deep Tumors Analysis of Six Years Experience (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO). Los Angeles, California, November 5-8, 1992.
    
41. Surowiec, A. Bicher HI, Evaluation of Multiplane Sar Distribution of Hyperthermia Applicators by Means of Liquid-Crystal Card and Polyacrylamide Phantom System (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO). Los Angeles, California, November 5-8, 1992.
    
42. Surowiec, A. Bicher HI, Caridad, C. Vinh, F. Heating Characteristics of Tripas Systems (Abstract). Proceeding of the 9th Annual Meeting of the American Society of Clinical Hyperthermic Oncology (ASCHO). Los Angeles, California, November 5-8, 1992.
    
43. Bicher HI, Bruley, D. F. Changes in tissue oxygenation and Acidity induced by localized Microwave Hyperthermia and Hematoporphyrin Phototherapy, an Update*. From OXYGEN TRANSPORT TO TISSUE –IV.
    
44. Bicher HI, Wolfstein, RS, Burmistrovich, B. Tressia, K. Thermoradiotherapy for Prostate Cancer. Hyperthermic Oncology 1996. Volume II. Proceedings of the 7th International Congress on Hyperthermia Oncology Roma, Italy April 9-13 1996.
    
45. Bicher HI, Wolfstein, RS. MD., Boris Boris Burmistrovich MD., Tressia Keen, MN. Effect of Tumor Stage and Frequency of treatment on local response to Thermoradiotheraphy. Proceedings of the 7th. ICHO. Roma, Italy. April 9-13, 1996
    
46. Bicher HI, Wolfstein, RS MD., Keen, T., MN, Carter, S., PHD. Thermoradiotherapy in breast cancer-the treatment of localized inflammatory recurrence. Proceedings of the twenty Second meeting of the International Clinical Hyperthermia Society, Marina del rey, California USA. From September 23rd – 25th , 1999
    
47. Bicher HI. MD. Thermoradiotherapy Fractionation in the Clinical treatment of malignant tumors. Proceedings of the twenty second meeting of the International Clinical Hyperthermia Society. Marina del Rey, California USA. From September 23rd- 25th , 1999.
    
48. Bicher HI. MD.,Wolfstein, RS. MD.,Tressia Keen, M.N., Sylvia Carter, Ph.D. An Update on the treatment of localized inflammatory breast cancer recurrence. Valley Cancer Institute, Los Angeles, California. USA. Proceedings of the twenty Third meeting of the ICHO. Lyon France. June 15-17, 2000.
    
49. Bicher HI MD.; Wolfstein, RS. M.D.; Tressia Keen M.N. and Silvia, Carter RTT. Low Dose Hyperfractioned Thermoradiotherapy in the Clinical Treatment of Malignant Tumors. . Proceedings of the 18th Annual Meeting N.A.H.S. in Philadelphia, Pensylvania. USA. April 8-10, 1999.
    
50. Bicher HI MD.; Wolfstein, RS. M.D. Thermoradiotherapy Treatment for prostate cancer-an update.Proceedings of the 48th RRS / 18TH N.A.H.S. in San Juan, Puerto Rico. April 21st-25th, 2001.
    
51. Bicher HI MD.; Wolfstein, RS. M.D.; Tressia Keen M.N. and Sylvia, Carter RTT. Thermoradiotherapy in breast cancer-The treatment of localized inflammatory recurrence. Proceedings of the ESHO, Verona, Italy, May 30th-June 2nd, 2001.
    
52. Bicher HI MD. Thermoradiotherapy Treatment of malignant tumors. Fractionation regime and objective end points. Proceedings of the XXIV ICHS Rome-Pavia, Italy September 24th-29th, 2001.
    
53. Bicher HI MD.; Wolfstein, RS. M.D.; Tressia Keen M.N. and Sylvia, Carter RTT.; and Garwood, Michael. Ph.D. Thermoradiotherapy in Breast cancer. Treating with curative intent and objective end point parameters. Proceedings of the XXIV ICHS Rome- Pavia, Italy September 24th-29th, 2001.
    
54. Bicher HI MD.; Wolfstein, RS. M.D.; Tressia Keen M.N. and Sylvia, Carter RTT.; and Garwood, Michael. Ph.D. Thermoradiotherapy in Breast cancer. Treating with curative intent and objective end point parameters. Proceedings of the 49th Radiation Research Society, 20th NAHS, Reno, Nevada, USA. April 20th-24th, 2002.
    
55. Bicher HI MD. Protracted Thermoradiotherapy, treating to effect with objective end points. Proceedings of the XXV ICHS Destin, Florida, USA, October 16th-19th, 2002
    
56. Bicher HI MD, Mitagvaria NP PhD, Nebieridze MI MD. Local Hyperthermia treatment results in significant morphological changes in rats’ brain tissue. Proceedings of the XXVI ICHS Shenzhen, China, September 10th-12th, 2004.
    
57. Bicher HI MD., Wolfstein, RS. M.D. Thermoradiotherapy with curative intent – breast, head and neck and prostate tumors. Proceedings of the XXVII ICHS Florence, Italy, October 27th – 28th, 2005.
    
58. Bicher HI MD., Wolfstein, RS. M.D. Thermoradiotherapy with curative intent – breast, head and neck and prostate tumors. Deutsche Zeitschrift für Onkologie (German Journal of Oncology) 2006, 38: 116-122.
    
59. Bicher HI MD., Wolfstein, RS. M.D A Method of Curative Thermoradiotherapy in Superficial Tumors; Breast, Head and Neck, and Prostate – An Update. Proceedings of the STM Tucson, Florida, USA, April 3-7, 2010
    
60. Bicher HI MD., Wolfstein, RS. M.D, Hyperfractionated Thermoradiotherapy (HTRT) Causes Less Sexual Dysfunction than External Beam Radiation Therapy (EBRT) in Definitive Treatment of Prostate Cancer. Proceedings of the STM, Clearwater,Arizona, USA, April 24-27, 2009

Head and Neck

Clinical Trials

Publications by James Bicher